Job Description

Job Description:

We are seeking a dedicated and detail-oriented Associate Scientist/Sr. Associate Scientist to join our Chemistry team in developing next-generation RNAi medicines. The ideal candidate will be highly motivated, passionate about early-discovery work, eager to learn, and capable of adapting flexibly to a dynamic work environment.

Primary Responsibilities:

• Independently perform every step of the oligonucleotide synthesis process, from small scale to medium scale synthesis to cleavage & deprotection to purification/desalting and characterize compounds.
• Synthesize and analyze substituted oligonucleotides containing a variety of chemical modifications in support of internal programs, partnered programs, and platform work.
• Operate, troubleshoot, and maintain laboratory equipment, purification, and analytical instruments such as Agilent HPLC system, AKTA purifier, UPLC, LCMS, and other state-of-the-art laboratory equipment, ensuring their proper use and performance.
• Closely work with biologists to communicate timelines and facilitate synthesis requests
• Track progress, generate status updates, organize experimental data, and present in both written and oral formats at cross-functional team meetings.
• Prepare SOPs and accurately record detailed experimental procedures and results in electronic lab notebooks.

Qualifications:

• BS or MS in Chemistry or a related field.
• At least 2-3 years of chemistry lab experience in an industrial or academic setting, preferably in RNA therapeutics.
• Strong knowledge of organic chemistry and/or oligonucleotide chemistry, including solid-phase oligonucleotide synthesis, purification by HPLC, analysis of impurities, and characterization of compounds by mass spectrometry etc.
• Strong focus on lab work with ability to work independently and cooperatively in a team environment.
• Proficient in data analysis and ELN record-keeping, with good documentation practices.
• Quick learner with a passion for early-discovery work.
• Ability to handle urgent tasks and adapt to new directions quickly in a fast-paced work environment.
• Excellent communication and presentation skills.

City Therapeutics is accepting resumes/CVs from direct applicants only. Recruitment Agency submissions will not be accepted at this time.

City Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law. City Therapeutics

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